Publications by authors named "V M Kozlov"
Background: Prolgolimab is an IgG1 anti-PD-1 monoclonal antibody with the Fc-silencing 'LALA' mutation. The phase III DOMAJOR study assessed efficacy and safety of prolgolimab in combination with pemetrexed and platinum-based chemotherapy vs placebo in combination with pemetrexed and platinum-based chemotherapy as first-line treatment for advanced non-small cell lung cancer (NSCLC).
Methods: 292 patients with advanced non-squamous NSCLC were randomized 1:1 to receive 4 cycles of pemetrexed, platinum-based drug and either prolgolimab (3 mg/kg Q3W) or placebo followed by prolgolimab/placebo with pemetrexed until disease progression or toxicity (≤36 months).
In recent years, hyaluronic acid (HA) has attracted increasing attention as a promising biomaterial for the development of drug delivery systems. Due to its unique properties, such as high biocompatibility, low toxicity, and modifiability, HA is becoming a basis for the creation of targeted drug delivery systems, especially in the field of oncology. Receptors for HA overexpressed in subpopulations of cancer cells, and one of them, CD44, is recognized as a molecular marker for cancer stem cells.
View Article and Find Full Text PDFThe use of metal and metal oxide nanoparticles is frequently regarded as a potential solution to the issue of bacterial antibiotic resistance. Among the proposed range of nanoparticles with antibacterial properties, copper oxide nanoparticles are of particular interest. Although the antibacterial properties of copper have been known for a considerable period of time, studies on the effects of copper oxide nanomaterials with respect to biological systems have attracted considerable attention in recent years.
View Article and Find Full Text PDFDevelopment of new antibacterial materials for solving biomedical problems is an extremely important and very urgent task. This review aims to summarize recent articles (from the last five and mostly the last three years) on the nanoparticle/polymer composites for biomedical applications. Articles on polymeric nanoparticles (NPs) and hydrogel-based systems were not reviewed, since we focused our attention mostly on the composites of polymeric matrix with at least one inorganic filler in the form of NPs.
View Article and Find Full Text PDFArticle Synopsis
- - Lung cancer rates in Russia, particularly among men, have declined since the 1990s due to reduced smoking, but recent trends show rising incidence rates, especially in women since 2012, while mortality rates remain stable.
- - The study utilized national cancer reports and the Russian Fertility and Mortality Database from 1965-2021 to analyze changes in lung cancer incidence and mortality, revealing significant shifts starting around 2013 for men and 2012 for women.
- - An increase in the use of CT scans coincides with these trends, suggesting the need for ongoing monitoring to assess the impact of improved diagnostic methods on lung cancer outcomes in Russia.