[Changes in central hemodynamics and gas exchange after a single and scheduled administration of obsidan in patients with exertion-induced stenocardia and various types of blood circulation].

Sixty-two patients with angina of effort and different circulation types were investigated to assess the pattern of changes in hemodynamics and gas exchange following an acute obsidan test and a course of obsidan treatment. A relationship was demonstrated between the effect of obsidan on central hemodynamics and gas exchange, on the one hand, and the baseline circulatory type, on the other. In patients with hyper- and eukinetic circulation, the drug increased the maximum oxygen uptake and total performance volume in the presence of a variety of hemodynamic changes; such as the negative inotropic and chronotropic effects in the hyperkinetic-type patients, and the negative chronotropic effect in the eukinetic-type ones.

[Central hemodynamics and oxygen supply in patients with ischemic heart disease associated with chronic bronchitis].

A comparative study of central hemodynamics and systemic oxygen supply was carried out with reference to hemodynamic type in patients with uncomplicated coronary heart disease (CHD) and CHD combined with chronic nonobstructive bronchitis. Patients with combined pathology and hyper- or hypokinetic circulation type showed the same hemodynamic pattern at rest and oxygen supply during exercise, as did coronary patients with similar circulation types, that suggested latent heart failure and were more marked in patients with hypokinetic circulation. In coronary patients with chronic bronchitis and eukinetic circulation, central hemodynamics and oxygen supply were impaired, as compared to coronary patients with similar circulation types.

[Smoking and the status of the cardiorespiratory system in patients with exertion-induced stenocardia].

Oxygen support of exercise was examined in normal subjects and anginal patients, both smokers and non-smokers. In normal subjects, smoking was not associated with significant changes in oxygen consumption and the double product, whereas total output was significantly smaller in the smokers, as compared to the nonsmokers. The smoking patients with angina of effort showed significantly reduced oxygen consumption, coupled with increased myocardial oxygen requirement.

[Indicators of spiroveloergometry and the sympathetic-adrenal system in patients with exertion-induced angina pectoris with different types of circulation].

The response of the cardiorespiratory and sympathoadrenal (SA) systems to exercise in coronary heart disease patients was found to depend on the hemodynamic type of circulation and the initial activity of the SA system. In patients with the hyperkinetic type of the circulation showing a high initial activity of the SA system and the absence of its response to exercise, the authors observed an increased consumption of oxygen both at rest and during mild exercise which indicated that oxygen expenditure in these patients was ineffective, and subsequently led to a reduction in their capacity to do physical work. Patients with the hypokinetic circulation type and an initially low activity of the SA system exhibited a considerable elevation in the activity of the hormonal component of the SA system during exercise.

[Effect of obzidan on the indices of gas exchange and the sympathetic-adrenal system in ischemic heart disease patients with different types of circulation].

The relationship between the effect of propranolol treatment on oxygen consumption during exercise and the activity of the sympathoadrenal system (SAS) and the initial hemodynamic circulatory type was established in patients with coronary heart disease (CHD). In patients with the hyper- and eukinetic circulatory types, propranolol caused an increase in the maximal oxygen consumption (MOC), pointing to the improvement of the functional possibilities of the cardiovascular system during exercise, with this improvement being more marked in patients with the hyperkinetic type. This effect of propranolol in the latter group patients was coupled with a reduction in the transmitter activity of the SAS.