Publications by authors named "V M Factor"
Article Synopsis
- High-fat diets contribute significantly to metabolic dysfunctions like metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH), with mitochondria implicated in their development.
- The study investigates the role of mitochondrial topoisomerase I (Top1MT) by using mice that lack this enzyme, revealing that these mice are more susceptible to severe MASH after being fed a high-fat diet for 16 weeks.
- Findings show that Top1MT deficiency leads to severe liver issues, mitochondrial dysfunction, increased reactive oxygen species production, and enhanced hepatic inflammation, underscoring its critical role in maintaining liver cell health and preventing MASH.
Article Synopsis
- Several types of human stem cells are utilized to create 3D liver organoids for research on liver disease and physiology, with a new method allowing primary human hepatocytes to be converted into bipotent progenitor cells for this purpose.
- The study compared organoids derived from these progenitor cells to those from human liver cells and induced pluripotent stem cells, highlighting their molecular traits and potential for biomedical applications.
- Findings indicate that the new bipotent progenitor-derived organoids show superior characteristics, better mimic liver disease conditions, and enhance sensitivity in drug toxicity testing compared to traditional liver cell-derived organoids.
Colorectal cancers (CRCs) are prevalent worldwide, yet current treatments remain inadequate. Using chemical genetic screens, we identify that co-inhibition of topoisomerase I (TOP1) and NEDD8 is synergistically cytotoxic in human CRC cells. Combination of the TOP1 inhibitor irinotecan or its bioactive metabolite SN38 with the NEDD8-activating enzyme inhibitor pevonedistat exhibits synergy in CRC patient-derived organoids and xenografts.
View Article and Find Full Text PDFCholangiopathy is a diverse spectrum of chronic progressive bile duct disorders with limited treatment options and dismal outcomes. Scaffold- and stem cell-based tissue engineering technologies hold great promise for reconstructive surgery and tissue repair. Here, we report a combined application of 3D scaffold fabrication and reprogramming of patient-specific human hepatocytes to produce implantable artificial tissues that imitate the mechanical and biological properties of native bile ducts.
View Article and Find Full Text PDFPurpose: Biliary tract cancer (BTC) is a heterogeneous group of rare gastrointestinal malignancies with dismal prognosis often associated with inflammation. We assessed the prognostic value of IL6 and YKL-40 compared with CA19-9 before and during palliative chemotherapy. We also investigated in mice whether IL6R inhibition in combination with gemcitabine could prolong chemosensitivity.
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