Publications by authors named "V M F Meijborg"
Article Synopsis
- Hypothermic oxygenated perfusion (HOPE) is a new technique being tested to preserve donor hearts, showing positive early results in clinical trials.
- Unlike other organs, cardiac HOPE includes red blood cell (RBC) supplementation, even though there's limited evidence proving its effectiveness.
- While initial findings on RBC use during cardiac HOPE are encouraging, there may be drawbacks that need more research to enhance heart preservation methods.
Article Synopsis
- The study investigates the structure of trabeculations in the heart ventricles of pigs compared to humans, particularly in the context of xenotransplantation.
- It was found that pig hearts have fewer but larger trabeculations, yet a closer look reveals they also have numerous tiny trabeculations that are still larger than those in embryos.
- The research concludes that the growth patterns of trabecular and compact layers don't follow the expected compaction process, showing that trabecular morphology and its proportion to compact myocardium are influenced by different factors.
An electrical storm of Torsade de Pointes arrhythmias (TdP) can be reproducibly induced in the anesthetized chronic AV-block (CAVB) dog by infusion of the I-blocker dofetilide. Earlier studies showed that these arrhythmias 1) arise from locations with high spatial dispersion in repolarization (SDR) and 2) can be suppressed by high-rate pacing. We examined whether suppression of TdP by high-rate pacing is established through a decrease in SDR in the CAVB dog.
View Article and Find Full Text PDFThe body surface electrocardiogram (ECG) is a direct result of electrical activity generated by the myocardium. Using the body surface ECGs to reconstruct cardiac electrical activity is called the inverse problem of electrocardiography. The method to solve the inverse problem depends on the chosen cardiac source model to describe cardiac electrical activity.
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