Integrated network pharmacology approach shows a potential role of Ginseng catechins and ginsenosides in modulating protein aggregation in Amyotrophic Lateral Sclerosis.

Unlabelled: Amyotrophic lateral Sclerosis is an incurable, progressive neurodegenerative motor neuron disease. The disease is characterized by protein aggregates. The symptoms include weakness, denervation of muscles, atrophy and progressive paralysis of bulbar and respiratory muscles and dysphagia.

Nucleotides modulate synoviocyte proliferation and osteoclast differentiation in macrophages with potential implications for rheumatoid arthritis.

Unlabelled: P2 receptors are nucleotide-activated receptors involved in inflammation, cell proliferation osteoblastogenesis, osteoclastogenesis and their function. They can be potential role players in the pathophysiology of rheumatoid arthritis (RA). Our analysis of gene expression datasets of synovial tissue biopsy from the GEO database shows changes in the expression levels of P2 receptors.

Butterfly-Shaped Thiophene-Pyridine Hybrids: Green Electroluminescence and Large Third-Order Optical Nonlinearities.

A set of four symmetric, butterfly-shaped 4-(4-(decyloxy)phenyl)-2,6-di(thiophen-2-yl)pyridine (TPY) derivatives 2TPA-TPY (TPY center and triphenylamine end groups), 2CBZ-TPY (TPY center and N-ethyl carbazole end groups), 2TPY-TPA (triphenylamine center and TPY at the periphery) and 2TPY-CBZ (N-ethyl carbazole center and TPY at the periphery) was synthesized. The molecules show reverse saturable absorption (RSA) which is consistent with two-photon absorption (2PA) associated with excited-state absorption (ESA) when excited using a 532 nm laser beam. The molecules 2TPA-TPY and 2TPY-TPA possess extremely low limiting thresholds of 1.

A comparison of decontamination methods of tried-in preformed metal crowns: an in-vivo study.

Aim: To compare the effectiveness of different decontamination methods on tried-in preformed metal crowns (PMCs).

Methods: Sixty unused PMCs and 90 tried-in PMCs from patients were assessed for contamination after culturing for 24 h on liquid media, solid media and differential media for identification of Streptococcus mutans, Staphylococcus aureus, and Escherichia coli. Subsequently, these PMCs were divided equally into the following six groups: autoclave (121 °C, 15 psi for 15 min), 5% sodium hypochlorite (5 min), 5% glutaraldehyde (5 min), 70% isopropyl alcohol (1 min) and normal saline (5 min).

Preferential Face-on and Edge-on Orientation of Thiophene Oligomers by Rational Molecular Design.

Precise control over the supramolecular organization of organic semiconducting materials guiding to exclusive face-on or edge-on orientation is a challenging task. In the present work, we study the preferential packing of thiophene oligomers induced through rational molecular designing and self-assembly. The acceptor-donor-acceptor-type oligomers having 2-(1,1-dicyano-methylene)rhodanine as acceptor (OT1) favored a face-on packing, whereas that of functionalized with N-octyl rhodanine (OT2) preferred an edge-on packing as evident from 2D-grazing incidence angle X-ray diffraction, tapping-mode atomic force microscopy (AFM) and Raman spectroscopy analyses.