Publications by authors named "V M Coyle"
Article Synopsis
- Sarcopenia, a muscle-wasting syndrome, is prevalent among older patients with advanced colorectal cancer and is exacerbated by chemotherapy, leading to increased toxicity, reduced quality of life, and lower survival rates.
- This review systematically evaluated existing studies on the effects of physical activity and nutritional interventions on muscle mass specifically in patients with advanced colorectal cancer, identifying gaps in research focused on this demographic.
- Out of twelve studies reviewed, most reported heterogenous interventions, with a few demonstrating benefits from protein supplementation, aerobic exercise, and resistance training, though challenges included low recruitment rates and moderate to high risk of bias.
In the past 5 years, real-time health monitoring has become ubiquitous with the development of watches and rings that can measure and report on the physiological state. As an extension, real-time biomarker sensors, such as the continuous glucose monitor, are becoming popular for both health and performance monitoring. However, few real-time sensors for biomarkers have been made commercially available; this is primarily due to problems with cost, stability, sensitivity, selectivity, and reproducibility of biosensors.
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- NUC-3373 is an experimental drug designed to improve the treatment of advanced solid tumors by being a more effective alternative to 5-fluorouracil (5-FU), which has drawbacks like poor conversion to active form and high toxicity.
- The drug was tested on patients with persistent tumors, administered through IV, and aimed to determine the maximum tolerated dose (MTD) and assess its effectiveness and safety.
- Results showed NUC-3373 was generally well-tolerated, had a favorable pharmacokinetic profile, and provided stable disease responses in patients previously treated with traditional therapies, with the MTD established at 2500 mg/m weekly.
Article Synopsis
- Neutropenic sepsis is a frequent issue for cancer patients undergoing treatment, leading to different practices regarding when to switch from intravenous (IV) to oral antibiotics.
- The study aimed to assess the clinical and cost-effectiveness of switching to oral antibiotics early for low-risk patients compared to standard IV care.
- The trial included 129 participants from 19 UK oncology centers but was closed early due to not meeting recruitment goals, preventing a definitive conclusion about the effectiveness of the early switch.