[Peculiarities of disorders in physical development of children consuming drinking water with increased nitrate content].

Peculiarities of physical development disorders in 334 children were examined in the course of comparative clinical-laboratory research; all these children consumed drinking water with various nitrates content (11.2±1.1 mg/l and up to 3.

[Development of lipids and carbohydrates metabolism disorders caused by drinkable water with high content of chlorine organic compounds].

Evaluation of effects caused by environmental peroral exposure to chlorine organic compounds revealed that individuals with AG variation of HTR2A gene are a community with increased sensitivity to chloroform and a risk group for lipid and carbohydrates metabolism disorders. Individual risk of endocrine disorders (ICD: E67.8 excessive nutrition and E66.

A mathematical model of the immune and neuroendocrine systems mutual regulation under the technogenic chemical factors impact.

The concept of the triad regulatory metasystem, which includes the neuroendocrine and immune regulation systems, is currently generally accepted. Changes occurring in each of the regulatory systems in response to the impact of technogenic chemical factors are also well known. This paper presents mathematical models of the immune and neuroendocrine system functioning, using the interaction between these systems in response to bacterial invasion as an example, and changes in their performance under exposure to chemical factors, taking into account the stage of functional disorders in a producing organ, using the performance of the bone marrow as an example.

[Prospects of occupational risk evaluation via modelling methods].

The article represents methodic approaches that enable quantitative evaluation of worker's health risk, forecast of changes in health state. Models application proved that integral risk of health disorders in workers exposed to occupational factors becomes unacceptable by the age of 45 years, without exposure to the factors - by 54 years. At work under existing levels of exposure to occupational factors, cardiovascular risk increases with length of service, and by 5 years of service, number of additional occupational cases in a studied group of workers approaches 11 per year.