Do Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio Need to Be Stratified for Age and Comorbidities in COVID-19 Disease? A Subgroup Analysis of Two Distinct Cohorts over Disease Course.

Several studies described neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) as markers of COVID-19 severity. In a recently published study, age and frailty affected NLR and PLR more than disease severity. The study compared two distinct cohorts.

Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio, are they markers of COVID-19 severity or old age and frailty? A comparison of two distinct cohorts.

The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are simple markers of systemic inflammatory responses. It has been previously suggested that they can predict COVID-19 severity. Age and frailty may also influence their values.

[Relationship between the structure, affinity to benzodiazepine receptors and properties of 5-halogenophenyl-1,2-dihydro-3H-1,4- benzodiazepine-2-ones].

The inhibition constants of [3H] diazepam specific binding with benzodiazepine receptor by 7-bromo-5-halogenophenyl-1,2-dihydro-3H-1,4-benzodiazepines change symbatically with molar extinctions of the longwave maxima in UV spectra, the basicity of these compounds and activity by the assays of antagonism with pentilentetrazol, the potentiation of hexenal sleep and disturbance of orientation reflexes. It has been suggested that anxiolytic, hypnosedative and antipentilentetrazol effects, and to lesser extent anticonvulsive and myorelaxant effects, of benzodiazepines and determined by affinity for benzodiazepine receptors.