Publications by authors named "V M Castellano-Megias"
Tissue biopsy remains the standard for diagnosing gastrointestinal stromal tumors (GISTs), although liquid biopsy is emerging as a promising alternative in oncology. In this pilot study, we advocate for droplet digital PCR (ddPCR) to diagnose GIST in tissue samples and explore its potential for early diagnosis via liquid biopsy, focusing on the D842V mutation and hypermethylated gene. We utilized ddPCR to analyze the predominant mutation (D842V) in surgical tissue samples from 15 GIST patients, correlating with pathologists' diagnoses.
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- Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is a newly recognized condition linked to Epstein-Barr virus and often arises in immunosuppressed patients, primarily affecting the oropharynx or skin, though rare cases occur in the colon.
- A 31-year-old man with ulcerative proctitis treated with azathioprine and adalimumab experienced a suspected flare-up, leading to hospital admission where he showed severe endoscopic activity but no infection was found.
- After starting intravenous steroids, his condition improved and he was discharged; subsequent histological analysis confirmed EBVMCU, leading to the discontinuation of his immunosuppressants while continuing steroid treatment and mesalazine with
Lanthanum carbonate is a non-calcium phosphorus chelator used in the treatment of hyperphosphatemia associated with chronic renal disease. Deposits of lanthanum in the gastrointestinal wall have been recently described but its clinical significance is uncertain. We present a case of a 62-year-old male with chronic renal disease treated with lanthanum carbonate for 3 years, with deposits in his gastric mucosa, found on biopsy for dyspepsia.
View Article and Find Full Text PDFIntraductal papillary mucinous neoplasm (IPMN) of the pancreas is a noninvasive epithelial neoplasm of mucin-producing cells arising in the main duct (MD) and/or branch ducts (BD) of the pancreas. Involved ducts are dilated and filled with neoplastic papillae and mucus in variable intensity. IPMN lacks ovarian-type stroma, unlike mucinous cystic neoplasm, and is defined as a grossly visible entity (≥ 5 mm), unlike pancreatic intraepithelial neoplasm.
View Article and Find Full Text PDFCholangiocarcinoma (CC) arising from the large intrahepatic bile ducts and extrahepatic hilar bile ducts share clinicopathological features and have been called hilar and perihilar CC as a group. However, "hilar and perihilar CC" are also used to refer exclusively to the intrahepatic hilar type CC or, more commonly, the extrahepatic hilar CC. Grossly, a major distinction can be made between papillary and non-papillary tumors.
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