A Novel Nanoconjugate of Landomycin A with C Fullerene for Cancer Targeted Therapy: Studies.

Introduction: Landomycins are a subgroup of angucycline antibiotics that are produced by bacteria and possess strong antineoplastic potential. Literature data suggest that enhancement of the therapeutic activity of this drug may be achieved by means of creating specific drug delivery systems. Here we propose to adopt C fullerene as flexible and stable nanocarrier for landomycin delivery into tumor cells.

Estimating the effectiveness of various methods of evacuation of kidney stones, on the basis of data obtained on percentage of "stone free" and recurrent stone formation.

Using the materials of more than 200 scientific papers of recent years in this review it has been carried out analysis of the effectiveness and also discussed the merits and demerits of various methods of treatment of urinary stone diseases (USD). With this purpose, for the first time it has been carried out analysis of treatment quality of USD using more important quantitative parameters of treatment efficacy: 1--percentage of "stone free"; 2--percentage of recurrent stone formation. It has been emphasized on the higher effectiveness of treatment in combination of the method of ESWL with the methods of ascending litholysis.

Influence of cations and total protein of urine on the solubility and probability of urate stone formation in kidneys.

The solubility of uric acid kidney stones has been studied in water solutions containing ammonium ions, alkaline ions and alkaline earth metals. It was shown that the solubility of uric acid stones depends on the concentration of these cations. The shape of the dependence curve of uric acid stone solubility in solutions containing cations of ammonium, sodium, potassium, calcium and magnesium has an extreme character.

Physicochemical background for ambiguity of clinical recommendations in treating phosphate nephrolithiasis.

Efficiency of clinical recommendations for curing and prevention of phosphate nephrolithiasis founded on physicochemical investigations is unexpectedly low and apparently did not exceed 50%. We tried to consider possible physicochemical causes of this fact. For this purpose the influence of changes of urine pH and of calcium, phosphate and complexon concentrations on the probability of different precipitation phases of solid calcium phosphate has been reviewed.

Total blood and urine protein of urolithiasis patients with renal calculi of different chemical composition.

We determined total blood protein (TBP) and total urine protein (TUP) in healthy subjects and urolithiasis (UL) patients with renal calculi of different chemical composition: phosphate (CaP), oxalate (CaOx) and urate (HUr). We discussed the peculiarities of TBP and TUP distribution curves obtained and showed that the data on TBP and TUP do not make it possible to reliably single out patients with UL or determine the chemical composition of calculi in their kidneys. However, it was established that the comparison of TUP measurement results for UL patients using the Ponseau-S and sulfosalicylic acid methods makes it possible to reliably separate patients with Ca-containing calculi (CaP and CaOx) from those with HUr calculi.