Treatment of Acute Circulatory Failure Based on CO-O-Derived Indices: the Lactel randomized multicentre study.

Background: Acute circulatory failure is critical in ICU patients. CO-O-derived indices including the central venous-to-arterial CO difference (P(v-a)CO gap) and the P(v-a)CO gap/Ca-vO ratio are markers for global metabolic demand and tissue hypoxia.

Research Question: Does a resuscitation strategy using CO-O-derived indices improve tissular hypoperfusion compared to standard care?

Study Design And Methods: We conducted a randomized, prospective, multicenter, single-blind study in three ICUs.

Maintenance of beta-blockers and cardiac surgery-related outcomes: a prospective propensity-matched multicentre analysis.

Background: We investigated the effects of maintaining beta-blockers on the day of surgery on the incidence of atrial fibrillation and postoperative acute kidney injury (AKI) in patients undergoing cardiac surgery.

Methods: We conducted a multicentre prospective observational study with propensity matching on patients treated with beta-blockers. We collected their baseline patient characteristics, comorbidities, and operative and postoperative outcomes.

Connexin channels and hemichannels are modulated differently by charge reversal at residues forming the intracellular pocket.

Background: Members of the β-subfamily of connexins contain an intracellular pocket surrounded by amino acid residues from the four transmembrane helices. The presence of this pocket has not previously been investigated in members of the α-, γ-, δ-, and ε-subfamilies. We studied connexin50 (Cx50) as a representative of the α-subfamily, because its structure has been determined and mutations of Cx50 are among the most common genetic causes of congenital cataracts.

Should the Vasoactive Inotropic Score be a Determinant for Early Initiation of VA ECMO in Postcardiotomy Cardiogenic Shock?

Objectives: The authors investigated the role of early venoarterial extracorporeal membrane oxygenation (VA ECMO) implantation in patients with postcardiotomy cardiogenic shock (PCS) on mortality and morbidity when integrating vasoactive-inotropic score (VIS) and type of catecholamine support.

Design: A retrospective, multicenter, observational study with propensity-weight matching.

Setting: Four university-affiliated intensive care units.