Publications by V M Abeler

Publications by authors named "V M Abeler"

Am J Clin Pathol

April 2016

The study analyzed the role of hormone receptors (estrogen and progesterone) in 294 patients with uterine sarcomas over a long-term follow-up period.
Immunohistochemistry revealed that while the receptors were expressed in many tumors, their expression did not correlate with various clinicopathologic factors or overall survival for the entire cohort.
However, in stage I leiomyosarcoma, higher progesterone receptor scores were associated with longer overall survival, indicating its potential as a prognostic factor in this specific group.

Cytometry A

April 2015

Nuclear texture analysis evaluates the arrangement of pixel gray levels in microscopic images of cell nuclei and shows promise for cancer prognosis, particularly in uterine sarcomas.
A study involving 354 patients revealed that higher entropy-based adaptive nuclear texture features were associated with significantly better 5-year survival rates (72% vs. 36% for low values).
Combining DNA ploidy classification with texture feature values allowed for the stratification of patients into three risk groups, emphasizing the potential of these texture features as independent prognostic markers in clinical settings.

BMC Cancer

May 2014

The study analyzed 110 cases of ovarian carcinoma to identify chromosomal rearrangements that could lead to personalized therapies, noting that knowledge of these aberrations is currently lacking.
The researchers used two genomic screening techniques, karyotyping and high-resolution comparative genomic hybridization, to compare chromosomal abnormalities across different histological subtypes of ovarian carcinomas.
The identified chromosomal changes suggested a connection between low-grade serous carcinomas and borderline tumors, supporting the idea of a progression from benign lesions to cancer in ovarian carcinogenesis.

Hum Pathol

April 2014

Leiomyosarcoma (LMS) is a rare but deadly type of uterine cancer that often metastasizes and is resistant to chemotherapy.
The study compared gene expression between primary LMS tumors and their metastases, revealing 203 genes that were significantly different between the two groups.
Understanding these molecular differences could provide insights into tumor progression and help in developing better prognostic and therapeutic strategies for LMS.

Endocr Rev

June 2013

This review explores the molecular characteristics and development of rare malignant ovarian germ cell tumors (mOGCTs), focusing on their genomic aberrations and transcriptome profiles.
It compares mOGCTs with male testicular germ cell tumors (TGCTs), discussing their origins and developmental pathways, while highlighting key differences in their genomic and expression patterns.
The study presents integrated molecular profiles of the main mOGCT subtypes - dysgerminoma, yolk sac tumor, and immature teratoma - suggesting that their development involves various pathways and resembles pluripotent precursor cells.