Publications by authors named "V Lukinsone"

Significance: Multispectral imaging enables mapping of chromophore content changes in skin neoplasms, which helps to diagnose a pathology. Different types of light sources can be used for the imaging. Design of laser-based illuminators is more complicated and, consequently, they are more expensive than LED-based illuminators.

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The remitted photon path lengths in human skin can be estimated by modelling; however, there are very few experimental data available to validate the simulations. This study exploited the photon time of flight method where picosecond laser pulses at seven wavelength bands in the spectral range 560-800 nm were launched into forearm skin of 10 volunteers via an optical fiber. The pulses of back-scattered light were detected via another optical fiber placed at variable distance (1, 8, 12, 16 or 20 mm) from the input fiber, with subsequent analysis of their shapes for all 35 spectral-spatial combinations.

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It is widely known that not all of the treated cells survive after introduction of exogenous molecules via any physical method. Therefore, it is important to develop methods that would allow simultaneous evaluation of both molecular delivery efficiency and cell viability. This study presents Förster resonance energy transfer (FRET)-based method that allows molecular transfer and cell viability evaluation in a single measurement by employing two common fluorescent dyes, namely, ethidium bromide and trypan blue.

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