Publications by authors named "V Loizzi"
Haematological toxicity of PARP inhibitors in advanced ovarian cancer: A systematic review and meta-analysis.
Eur J Obstet Gynecol Reprod Biol
December 2024
Background: Poly (ADP-ribose) polymerase inhibitors (PARPis) are effective treatment options for patients with advanced ovarian cancer (OC). A typical adverse event (AE) of these agents is haematological toxicity, which represents the leading cause of treatment modification and discontinuation. This systematic review and meta-analysis aimed to analyse the risk of haematological AEs, including anaemia, neutropenia and thrombocytopenia due to the use of PARPis in patients with OC.
View Article and Find Full Text PDFObjectives: Endometrial carcinosarcoma is a rare, aggressive high-grade endometrial cancer, accounting for about 5% of all uterine cancers and 15% of deaths from uterine cancers. The treatment can be complex, and the prognosis is poor. Its increasing incidence underscores the urgent requirement for personalized approaches in managing such challenging diseases.
View Article and Find Full Text PDFBackground/objectives: Uterine carcinosarcomas (UCSs) are rare and aggressive malignancies with limited epidemiological data. This study aims to evaluate the clinical and pathological features and prognostic factors of UCS in a retrospective cohort of 80 patients, contributing to improved management strategies.
Methods: We conducted a retrospective analysis of UCS cases treated from 1995 to 2024 at three institutions.
Article Synopsis
- The rise in endometrial cancer diagnoses has led to more patients receiving extensive surgical treatments, which come with risks of complications like lymphedema and bleeding.
- Sentinel Lymph Node (SLN) sampling is a technique used successfully in breast cancer surgery that offers crucial information with less risk to patient outcomes, and it is also feasible for endometrial cancer patients.
- There is currently a lack of consensus on key aspects of SLN sampling for endometrial cancer, so this review aims to analyze existing literature to help standardize the procedure.