Publications by authors named "V Lepage"
Age data are essential for estimating life history parameters and are thus critical for population assessment, management, and conservation. Traditional vertebrae-based age estimation in elasmobranchs can be costly, time intensive, of low accuracy, and is by necessity lethal. Herein, epigenetic clocks were developed for an elasmobranch, the cownose ray (Rhinoptera bonasus), using aquarium-born individuals (n = 42) with known dates of birth (age range: 7-7,878 days or 0-21 years) and two tissue types (fin clips and whole blood) that can be sampled in a relatively non-invasive manner.
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- Monoclonal antibodies, specifically a combination of trastuzumab, pertuzumab, and T-DM1, were compared to trastuzumab alone in treating HER2+ metastatic cancer to assess overall survival (OS) and progression-free survival (PFS).
- The study involved 82 patients from February 2008 to August 2022, revealing that patients in the combination therapy group (Arm A) had significantly longer OS (59 months) compared to those on trastuzumab alone (52 months) and also had longer overall treatment duration.
- While Arm A showed a notable reduction in the risk of death (Hazard Ratio = 0.59), there was no difference in
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- The study aimed to identify the presence of Lactococcus petauri, L. garvieae, and L. formosensis in fish and environmental samples near a fish farm outbreak in California during 2020, and compare their virulence in different fish species.
- Researchers isolated Lactococcus spp. using bacterial culture methods and detected their DNA through quantitative PCR in various fish tissues and environmental samples from four lakes.
- Results showed Lactococcus garvieae in Largemouth Bass and indicated that Rainbow Trout infected with L. petauri had high mortality rates, while Largemouth Bass did not show infection symptoms, highlighting the use of qPCR for monitoring and variances in bacterial virulence.
Magnesium chloride in high concentration is used for euthanasia of jellyfish to limit overpopulation and for predatory species consumption, but its use could lead to magnesium bioaccumulation and subsequent negative effects in consumers. Two species of scyphozoan jellyfish (Cassiopea andromeda and Aurelia aurita) were subjected to freezing (control), or magnesium chloride baths (144 g/L), with subsequent 30 min baths (one or two) in fresh artificial saltwater and submitted for inductively coupled plasma analysis to determine tissue concentration. Frozen jellyfish consistently yielded the lowest magnesium concentrations, while magnesium chloride euthanized individuals contained the highest concentrations in both species.
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