Beyond the Marrow: Unveiling Uncommon Sites of ALL Relapse with F-FDG PET/CT.

Extramedullary infiltration of acute lymphoblastic leukemia/lymphoma (ALL) to genital organs is extremely rare. Here, we present a case report of an asymptomatic 49-year-old female, known case of precursor B-cell ALL, who was incidentally detected with thickened and heterogeneously hyperechoic endometrium on sonography. Contrast magnetic resonance imaging detected large polypoidal enhancing lesions showing intense diffusion restriction occupying the endometrial cavity and similar lesions in the left adnexa, left ovary, and fallopian tube which were suspicious for leukemic infiltration because of the clinical history and atypical appearance of the lesions.

Trifecta of Tumors: Simultaneous Detection of Three Primary Malignancies by Different Radiotracers of Nuclear Medicine.

Malignancies are increasing worldwide with changing lifestyle, pollution, increasing life expectancy, and diagnostic advancements. However, multiple primary malignancies (MPMs) detected simultaneously are very rare. Here, we present a rare case of three primary malignancies (sigmoid colon, prostate, and thyroid) detected simultaneously in a 77-year-old male patient, who initially presented with bleeding per rectum and was then found to have a large pedunculated mass in the sigmoid colon on colonoscopy, which further turned out to be adenocarcinoma.

Impact of Respiratory-gated 4D PET/CT Scan for Motion Correction in Characterizing Lesions Adjacent to the Diaphragm - A Cross-sectional Study at a Tertiary Care Institute.

Purpose: The blur introduced by breathing motion degrades the diagnostic accuracy of whole-body F-18 fluorodeoxyglucose positron emission tomography-computed tomography (F-FDG PET-CT) in lesions adjacent to the diaphragm by increasing the apparent size and by decreasing their metabolic activity. This study aims to evaluate the efficacy of motion correction by four-dimensional phase-based respiratory-gated (RG) F-FDG PET-CT in improving metabolic parameters of lesions adjacent to the diaphragm (especially in the lungs or liver).

Materials And Methods: Eighteen patients with known lung or liver lesions underwent conventional F-FDG PET-CT and respiratory-gated PET-CT acquisition of the desired region using a pressure-sensing, phase-based respiratory-gating system.