Total Sulfur Amino Acid Requirements Are Not Altered in Children with Chronic Renal Insufficiency, but Minimum Methionine Needs Are Increased.

The total sulfur amino acid (TSAA) and minimum Met requirements have been previously determined in healthy children. TSAA metabolism is altered in kidney disease. Whether TSAA requirements are altered in children with chronic renal insufficiency (CRI) is unknown.

Minimum methionine requirement and cysteine sparing of methionine in healthy school-age children.

Background: Cysteine can provide a portion of the sulfur amino acid requirement in adults. Whether this is true in children-and, if so, to what extent-is not known.

Objectives: The objectives were to determine minimum methionine requirements in healthy, school-age children when excess cysteine is provided and to subsequently determine the cysteine-sparing effect by comparing these methionine requirements with those determined previously in the same children when no cysteine was provided.

Total sulfur amino acid requirement of healthy school-age children as determined by indicator amino acid oxidation technique.

Background: Current total sulfur amino acid (TSAA) requirements of children are based on a factorial estimate that involves several assumptions.

Objective: The objective was to determine the TSAA requirement (methionine alone) of healthy school-age children by measuring the appearance of 13CO2 (F13CO2) in breath after the oxidation of l-[1-13C]phenylalanine in response to graded methionine intakes.

Design: Six healthy school-age children randomly received each of 6 methionine intakes (0, 5, 10, 15, 25, and 35 mg.

Nocturnal hemodialysis: three-year experience.

There is evidence that high frequency, as well as long duration, hemodialysis provides better clinical outcomes. We developed nocturnal hemodialysis, a new innovative form of renal replacement therapy, which is performed six to seven nights per week for 8 to 10 h during sleep at home. Blood flow was set at 300 ml/min and dialysate flow at 100 ml/min.