Multicenter approach to predict plan quality of robotic intracranial SRS/SRT.

Purpose: This study analyzed inter-institute conformity and dose gradient variability of CyberKnife (CK) brain SRS/SRT plans. The feasibility of multi-center predictive models was investigated, aiming at guided/automated planning optimization.

Methods: Data from 335 clinical plans, delivered for single lesions in 1-5 fractions, were collected by 8 CK centers.

The impact of obesity on sleep, pulmonary and chest wall restriction in Osteogenesis Imperfecta: a pilot study.

Introduction: Osteogenesis Imperfecta (OI) is characterised by brittle bones, severe skeletal deformities, low sleep quality, and restricted breathing. We aimed to distinguish how disease and obesity affect these results.

Methods: According to BMI, we considered four groups of peer adults (median age: 35.

Stereotactic Radiation Therapy in 3 Fractions for T1 Glottic Cancer.

Purpose/objective(s): To report the results of a phases 1 and 2 study on stereotactic body radiation therapy (SBRT) for early glottic cancer.

Methods And Materials: This a prospective study at a single institution enrolling patients with T1 glottic cancer. The true vocal cords (TVCs) were divided into thirds and the third(s) containing disease prescribed 36 Gy in 3 fractions.

The RNA from Pseudomonas aeruginosa Reduces Neutrophil Responses Favoring Bacterial Survival.

Introduction: Epithelial and endothelial cells modulate innate immune responses in the lung, including the arrival of neutrophils (PMN), which are crucial cells for the antibacterial host defense. Cells are exposed to prokaryotic RNA (pRNA) during bacterial infections and different pRNA may promote or attenuate the inflammatory response on different immune cells. Pseudomonas aeruginosa (PAE) can cause severe pneumonia and has several immune-evading mechanisms.

Therapeutic Management of Bronchiectasis in Children and Adolescents: A Concise Narrative Review.

: Bronchiectasis, characterized by airway dilation, mucus hypersecretion, and recurrent exacerbations, is increasingly recognized in children and adolescents. Recent guidelines from the European Respiratory Society (ERS) and Thoracic Society of Australia and New Zealand (TSANZ) emphasize early diagnosis and optimized management. This review explores therapeutic strategies for pediatric bronchiectasis.