Publications by authors named "V Lamontagne"
Article Synopsis
- Diaphragmatic hernias are common in older adults and generally result in mild digestive and breathing issues.
- A case is presented where an elderly man, after undergoing cardiac surgery, experienced severe respiratory distress due to a large diaphragmatic hernia, necessitating emergency surgery.
- The findings suggest that acute diaphragmatic herniation can lead to significant breathing difficulties, and surgical intervention may be necessary for specific cardiac surgery patients.
Acute myeloid leukemias (AMLs) result from a series of genetic events occurring in a stem or progenitor hematopoietic cell that gives rise to their clonal expansion and an impaired capacity to differentiate. To circumvent the genetic heterogeneity of AML patient cohorts, we have developed a model system, driven by the MLL-AF9 (MA9) oncogene, to generate multiple human leukemias using progenitor cells from a single healthy donor. Through stepwise RNA-sequencing data generated using this model and AML patients, we have identified consistent changes associated with MA9-driven leukemogenesis and demonstrate that no recurrent secondary mutations are required.
View Article and Find Full Text PDFAcute myeloid leukemia (AML) occurs when hematopoietic progenitor cells acquire genetic defects blocking the regulation of normal growth and differentiation. Although recurrent translocations have been identified in AML, almost half of adult AML patients present with a normal karyotype (NK-AML). While cell line models exist to study AML, they frequently have abnormal/unstable karyotypes, while primary cells from NK-AML patients are difficult to maintain in vitro.
View Article and Find Full Text PDFDevelopment and validation of a questionnaire on musculoskeletal pain in musicians.
Med Probl Perform Art
March 2012
Musculoskeletal pain is known to be prevalent among musicians. Unfortunately, there are a lack of standard measures to quantify perceived pain in this population. The principal objective of the present study was to develop a self-reported questionnaire targeting musculoskeletal pain that is specific to musical activity.
View Article and Find Full Text PDFBackground: Adverse effects of high-fat diets (HFD) on metabolic homeostasis are linked to adipose tissue dysfunction. The goal of this study was to examine the effect of the HFD nature on adipose tissue activity, metabolic disturbances and glucose homeostasis alterations in male mice compared with female mice.
Methods: C57BL/6J mice were fed either a chow diet or HFD including vegetal (VD) or animal (AD) fat.