Cutaneous Innate Lymphoid Populations Drive IL-17A-Mediated Immunity in Nannizzia gypsea Dermatophytosis.

Fungal skin infections significantly contribute to the global human disease burden, yet our understanding of cutaneous immunity against dermatophytes remains limited. Previously, we developed a model of epicutaneous infection with Microsporum canis in C57BL/6 mice, which highlighted the critical role of IL-17RA signaling in antidermatophyte defenses. In this study, we expanded our investigation to the human pathogen Nannizzia gypsea and demonstrated that skin γδTCR and CD8/CD4 double-negative βTCR T cells are the principal producers of IL-17A during dermatophytosis.

CD39 expression by regulatory T cells participates in CD8+ T cell suppression during experimental Trypanosoma cruzi infection.

An imbalance between suppressor and effector immune responses may preclude cure in chronic parasitic diseases. In the case of Trypanosoma cruzi infection, specialized regulatory Foxp3+ T (Treg) cells suppress protective type-1 effector responses. Herein, we investigated the kinetics and underlying mechanisms behind the regulation of protective parasite-specific CD8+ T cell immunity during acute T.

Ameliorative effect of Vitis vinifera (Linn.) seed extract on lead acetate induced oxidative damage on testis and sperm quality in Wistar rats.

Lead is considered one of the most prevalent environmental and biologically hazardous toxicants among metallic elements. It severely affects human health and especially the male reproductive system by causing reproductive organ dysfunction leading to infertility. Natural dietary antioxidants are studied for their ability to ameliorate the cells' miscellaneous damage.