Publications by authors named "V Lakshminarayanan"
Article Synopsis
- - The Fast Melt Tablet (FMT) is a new type of quickly dissolving tablet that uses cocoa butter to melt at body temperature, enhancing its effectiveness when taken orally.
- - The study aimed to improve the taste of FMT containing memantine hydrochloride by using artificial sweeteners like aspartame and acesulfame K; six formulations were tested to find the best flavor masking.
- - Formulation T7, using 30mg of aspartame, was found to effectively mask the bitter taste and has desirable properties for commercialization, showing potential as an easy-to-take treatment for Alzheimer's disease.
Background: The Supplemental Nutrition Assistance Program (SNAP) is one of the most successful national programs to reduce poverty and improve health outcomes, but millions of Americans who qualify still do not have access to SNAP, and limited data is available to determine how referrals to the program can be completed successfully.
Objectives: We aimed to design and develop a standards-based digital care coordination platform to support closed-loop social services referrals between patients and social and health care providers; and demonstrate the feasibility to screen, diagnose, plan, and complete interventions with selected patients in real-settings.
Methods: We partnered with community members to design the platform through Community Engagement Studios and with a Federally Qualified Health Center, Local Mental Health Authority, and Food Bank to determine the features and workflow requirements of the platform design.
Article Synopsis
- * The research focused on comparing oven drying and freeze drying methods for creating orally disintegrating films (ODF) with memantine hydrochloride, assessing factors like the concentrations of Guar Gum, wheat starch, and PEG 400.
- * The study found that the optimal ODF formulation—containing 1.50 g each of guar gum, starch, and PEG 400—was developed through freeze drying, resulting in a flexible, fast-disintegrating film that could effectively serve as an alternative medication delivery method for Alzheimer's treatment.
Geriatric patients have difficulty to comply to their medication regimen due to complicated medication administration schedule, dysphagia, reduced ability to swallow tablets and dementia. This is particularly more challenging among the Alzheimer Disease's patients. Therefore, a model drug, memantine hydrochloride has been formulated into an orally disintegrating film (ODF) for easier consumption.
View Article and Find Full Text PDFThe oral route of drug administration is often preferred by patients and healthcare providers due to its convenience, ease of use, non-invasiveness, and patient acceptance. However, traditional oral dosage forms have several limitations, including low bioavailability, limited drug loading capacity, and stability and storage issues, particularly with solutions and suspensions. Over the years, researchers have dedicated considerable effort to developing novel oral drug delivery systems to overcome these limitations.
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