Fused thiophene derivatives as MEK inhibitors.

A number of novel fused thiophene derivatives have been prepared and identified as potent inhibitors of MEK. The SAR data of selected examples and the in vivo profiling of compound 13 h demonstrates the functional activity of this class of compounds in HT-29 PK/PD models.

Improving the number of mothers breastfeeding in the postpartum period.

The objective of this study was to review an experience at Jackson Memorial Hospital, Miami, Florida that has resulted in an increase in the percentage of mothers breastfeeding at postpartum discharge. Data was obtained from postpartum interviews in 1993, which provided the percentage of mothers breastfeeding at discharge. Staff members and personnel involved in the care of postpartum mothers and babies were educated about breastfeeding, and rounds were made to problem solve and reinforce.

Dermatology teleconsultations to Central Prison: experience at East Carolina University.

Objective: To review our experience with dermatology teleconsultations between East Carolina University School of Medicine in Greenville and Central Prison in Raleigh, NC.

Materials And Methods: Consultation forms kept on file in the Department of Internal Medicine served as the source of data. One physician reviewed the forms from the initial 22 months of our dermatology teleconsultation service to Central Prison.

Piezogenic wrist papules: a common and asymptomatic finding.

The first description of piezogenic wrist papules is presented. Twenty-nine persons were examined; 76% had pedal papules and 86% had wrist papules. Piezogenic papules are a common, nonhereditary finding and are not secondary to an inherent connective tissue defect.