Publications by authors named "V La Milia"
Article Synopsis
- Two patients developed severe hypophosphatemia requiring hospitalization after denosumab treatment for osteoporosis, despite having normal kidney function and no known risk factors.
- Both patients experienced neurological symptoms and severe fatigue, which improved with intravenous phosphate treatment, and they left the hospital with oral phosphate and vitamin D supplements.
- As denosumab use increases, it's important to monitor serum phosphate and related levels regularly, and to consider hypophosphatemia as a potential issue when patients report unexplained fatigue or muscle problems.
Exploring the global energy landscape of relatively large molecules at the quantum level is a challenging problem. In this work, we report the coupling of a nonredundant conformational space exploration method, namely, the robotics-inspired iterative global exploration and local optimization (IGLOO) algorithm, with the quantum-chemical density functional tight binding (DFTB) potential. The application of this fast and efficient computational approach to three close-sized molecules of the phthalate family (DBP, BBP, and DEHP) showed that they present different conformational landscapes.
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- - The article discusses a case of acute kidney injury resulting from ethylene glycol poisoning that showed partial recovery after temporary hemodialysis.
- - Diagnosis was made through evaluating the patient's clinical history and detecting ethylene glycol in the blood.
- - Renal biopsy revealed numerous intratubular crystals, and the urine analysis showed many unusual calcium oxalate crystals that were spindle-like and needle-like in shape.