Relationship between plasma and brain levels and the anticonvulsant effect of lamotrigine in rats.

The aims of the present research were to characterize the plasma and brain concentration-time profiles of lamotrigine after its acute administration and to establish the relationship between these profiles and the anticonvulsant effect of lamotrigine in rats. Adult male Wistar rats were given 10 mg/kg of lamotrigine intraperitoneally. The lamotrigine profiles in plasma and brain were determined at predetermined times over 120-h post-dose.

[Normal and pathological cardiac aging. Apropos of an exceptional case of longevity].

Born in Arles on February 21st 1875, Madame J. C. was the oldest registered human being.