Publications by authors named "V L Tanna"
Purpose: To compare the outcomes of intravitreal melphalan (IVit-M) versus intravitreal topotecan (IVit-T) for vitreous seeds (VS) in retinoblastoma (RB).
Design: Retrospective interventional study.
Participants: Patients of RB with VS receiving intravitreal chemotherapy (IVit-C) between December 2012 and December 2022, at a single quaternary ocular oncology referral center.
Article Synopsis
- The study looks at factors that can tell if a certain type of skin cancer, called eyelid and periocular sebaceous gland carcinoma (eSGC), will come back or spread in patients after treatment.
- Out of 355 patients studied, most hadn't had any treatment before coming to this research center. The treatments included surgeries, chemical therapy, and medications.
- Key factors that make the cancer more likely to return or spread included how the cancer looks, its size, if it spreads to nearby areas, and if there are positive margins in the tissue after surgery.
Oral Topiramate therapy is associated with systemic adverse effects including paresthesia,abdominal pain, and fluctuations in plasma levels. The purpose of this research was to develop an intranasal in situ gel based system comprising Topiramate polymeric nanoparticles and evaluate its potential both in vitro and in vivo. Poly (lactic-co-glycolic acid) (PLGA)nanoparticles prepared by nanoprecipitation method were added into the in situ gelling system of Poloxamer 407 and HPMC K4M.
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- The study aimed to analyze high-risk histopathological features in eyes with retinoblastoma (RB) after enucleation and compare patient outcomes globally.
- A total of 1,426 RB cases were reviewed, revealing significant differences in histopathological features across continents, with Asia showing the highest rates of massive choroidal invasion and optic nerve invasion.
- The findings indicated that patients from South America and Asia faced greater risks of tumor recurrence, systemic metastasis, and mortality compared to those from Australia, Europe, and North America.
Article Synopsis
- This study looked at how well a type of chemotherapy called platinum-based neoadjuvant chemotherapy (NACT) works for a particular kind of eyelid cancer called sebaceous gland carcinoma (eSGC).
- They treated 25 patients, and after the chemotherapy, many showed a significant reduction in tumor size, with 69% having complete control of the tumor after follow-up.
- The results suggest that NACT is a good treatment option for advanced eSGC, with serious side effects being pretty rare.