Publications by authors named "V L Shishkina"
A New Method of Intraoperative Modeling of Liver Cirrhosis in an Experiment.
Bull Exp Biol Med
January 2025
Article Synopsis
- A method was developed to model liver cirrhosis in male Wistar rats by performing a significant liver resection (about 70% volume).
- After surgery, one group received ademetionine while the control group got saline; both had various tests conducted on them over a 14-day period.
- Results indicated that the ademetionine group experienced notable liver dysfunction, with laboratory tests showing significant abnormalities, along with observable fibrotic, cirrhotic, and inflammatory liver changes that persisted beyond the testing period.
Article Synopsis
- Alzheimer's disease was experimentally induced in female Wistar rats through injections of β-amyloid into the hippocampus.
- Following this, olfactory mucosa cells were transplanted into the same brain region and showed survival and clustering by week 4.
- The transplanted cells improved cognitive functions significantly between weeks 3-5, suggesting potential for further research on these cells as a personalized treatment for Alzheimer's disease.
The review considers the use of exogenous neurotrophic factors in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and others. This group of diseases is associated with the death of neurons and dysfunction of the nervous tissue. Currently, there is no effective therapy for neurodegenerative diseases, and their treatment remains a serious problem of modern medicine.
View Article and Find Full Text PDFA new gene-cell construct expressing nerve growth factor (NGF) has been developed. After obtaining engineered adenovectors Ad5-RGD-CAG-NGF and Ad5-RGD-CAG-EGFP, transduction efficiency and transgene expression were studied and multiplicity of infection was determined. The efficacy of transduced human olfactory ensheathing cells expressing NGF in restoring motor activity in rats has been shown in a limited period of time.
View Article and Find Full Text PDFThis paper shows for the first time that co-transplantation of human olfactory ensheathing cells with neurotrophin-3 into spinal cord cysts is more effective for activation of remyelination than transplantation of cells with brain-derived neurotrophic factor and a combination of these two factors. The studied neurotrophic factors do not affect proliferation and migration of ensheathing cells in vitro. It can be concluded that the maximum improvement of motor function in rats receiving ensheathing cells with neurotrophin-3 is largely determined by activation of remyelination.
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