Contribution and quality of mathematical modeling evidence in World Health Organization guidelines: A systematic review.

Mathematical modeling studies are frequently conducted to guide policy in global health. However, the contribution of mathematical modeling studies to World Health Organization (WHO) guideline recommendations, and the quality of evidence contributed by these studies remains unknown. We conducted a systematic review of the WHO Guidelines Review Committee database to identify guideline recommendations that included evidence from mathematical modeling studies since inception of the Guidelines Review Committee on 1 December, 2007.

An evaluation of WHO emergency guidelines for Zika virus disease.

Background: In the face of an unclear causal association between Zika virus in utero exposure and congenital abnormalities and urgent demand for guidance, the World Health Organization (WHO) had to produce timely and trustworthy guidelines during the 2016 Public Health Emergency of International Concern (PHEIC).

Methods: This is a cross-sectional evaluation of WHO emergency guidelines produced during the Zika virus disease PHEIC from 1 February to 18 November 2016. We assessed adherence to WHO publication requirements and the reporting of guideline development processes associated with trustworthiness.

Correction: An evaluation of emergency guidelines issued by the World Health Organization in response to four infectious disease outbreaks.

[This corrects the article DOI: 10.1371/journal.pone.

An evaluation of emergency guidelines issued by the World Health Organization in response to four infectious disease outbreaks.

Background: The production of high-quality guidelines in response to public health emergencies poses challenges for the World Health Organization (WHO). The urgent need for guidance and the paucity of structured scientific data on emerging diseases hinder the formulation of evidence-informed recommendations using standard methods and procedures.

Objectives: In the context of the response to recent public health emergencies, this project aimed to describe the information products produced by WHO and assess the quality and trustworthiness of a subset of these products classified as guidelines.

Biased and inadequate citation of prior research in reports of cardiovascular trials is a continuing source of waste in research.

Objectives: We assessed citation of prior research over time and the association of citation with the agreement of results between the trial being reported and the prior trial.

Study Design And Setting: Groups of pharmacologic trials in cardiovascular disease were created using meta-analyses, and we assessed citation within these groups. We calculated the proportion of prior trials cited, the proportion of study participants captured in citations, and agreement of results between citing and cited trials.