Supraglottic devices: a possible role in prehospital toxic mass casualty event?

Rapidly progressive respiratory failure is the leading cause of death from inhalation of toxic chemical warfare agents. In an expected chaotic scenario, direct laryngoscopic tracheal intubation is unlikely to be easily and quickly performed due to shortage of medical personnel experienced with laryngoscopy and/or reduced dexterity imposed by the protective gear worn by the caregivers. Supraglottic devices have increasingly been used for emergent airway control in prehospital settings, thus avoiding the need for laryngoscopy.

Laryngeal mask airway insertion by anesthetists and nonanesthetists wearing unconventional protective gear: a prospective, randomized, crossover study in humans.

Background: Mass casualty situations impose special difficulties in airway management, even for experienced caregivers. The laryngeal mask airway is part of the difficult airway algorithm. The authors evaluated the success rate and the time to secure airways by mask by anesthetists, surgeons, and novices when wearing either surgical attire or full antichemical protective gear that included butyl rubber gloves and a filtering antigas mask.

Antichemical protective gear prolongs time to successful airway management: a randomized, crossover study in humans.

Background: Airway management is the first step in resuscitation. The extraordinary conditions in mass casualty situations impose special difficulties in airway management, even for experienced caregivers. The authors evaluated whether wearing surgical attire or antichemical protective gear made any difference in anesthetists' success of airway control with either an endotracheal tube or a laryngeal mask airway.

'Ecstasy' intoxication: life-threatening manifestations and resuscitative measures in the intensive care setting.

Objective: The ingestion of 3,4-methylenedioxymethamphetamine ('ecstasy') can cause severe neurological impairment and multi-system damage. We describe the potentially life-threatening clinical features and the management of intoxication by this psychedelic drug in patients transferred from emergency services to the intensive care area.

Methods: We conducted a retrospective analysis of 'ecstasy'-intoxicated patients admitted to a municipal hospital during a three-month period.

Flumazenil attenuates development of tolerance to diazepam after chronic treatment of mice with either isoflurane or diazepam.

Unlabelled: In an effort to clarify the mechanism of action of isoflurane, we studied the effect of flumazenil on mice chronically treated with isoflurane or diazepam. Mice were pretreated with diazepam, isoflurane, or saline, with and without flumazenil. After 2 wk, responses to isoflurane and diazepam were assessed, and central benzodiazepine receptor (CBR) binding characteristics were assayed.