Current Progress in the Development of mRNA Vaccines Against Bacterial Infections.

Bacterial infections have accompanied humanity for centuries. The discovery of the first antibiotics and the subsequent golden era of their discovery temporarily shifted the balance in this confrontation to the side of humans. Nevertheless, the excessive and improper use of antibacterial drugs and the evolution of bacteria has gotten the better of humans again.

[The dynamics of provision of population of the Russian Federation with otorhinolaryngologists in 2018-2023].

The most acute problem of state health care system is shortage of medical personnel, both physicians and paramedics. The purpose of the study is to assess dynamics of personnel support with otolaryngologists in medical organizations of the Russian Federation for 2018-2023. The retrospective analytical descriptive study was carried out using continuous method based on studying dynamics of personnel support with otolaryngologists in the Russian Federation in general, Federal Okrugs and particular Subjects of the Russian Federation for 2018-2023.

A Cap-Optimized mRNA Encoding Multiepitope Antigen ESAT6 Induces Robust Cellular and Humoral Immune Responses Against .

Tuberculosis is a deadly bacterial disease and the second most common cause of death from monoinfectious diseases worldwide. Comprehensive measures taken by health authorities in various countries in recent decades have saved tens of millions of lives, but the number of new cases of this infection has been steadily increasing in the last few years and already exceeds 10 million new cases annually. The development of new vaccines against tuberculosis is a priority area in the prevention of new cases of the disease.

A Two-Country Questionnaire Study of Biomedical Student Opinions Regarding Online Teaching During COVID-19.

Background: The purpose of this study was to compare the opinions of biomedical students from Russia and Central Serbia about learning methods in the time of the COVID-19 pandemic.

Methods: This is a comparative questionnaire study that used the validated questionnaire tool eMedQ, conducted via the online platform Anketolog.ru from February to May 2022 at Sechenov University and the University of Kragujevac in the same period.

Composition of lipid nanoparticles for targeted delivery: application to mRNA therapeutics.

Today, lipid nanoparticles (LNPs) are some of the main delivery systems for mRNA-based therapeutics. The scope of LNP applications in terms of RNA is not limited to antiviral vaccines but encompasses anticancer drugs and therapeutics for genetic (including rare) diseases. Such widespread use implies high customizability of targeted delivery of LNPs to specific organs and tissues.