Comparative transmetallation kinetics and thermodynamic stability of gadolinium-DTPA bis-glucosamide and other magnetic resonance imaging contrast media.

Rationale And Objectives: The relative stability and selectivity of magnetic resonance (MR) imaging contrast agents were compared with in vitro transmetallation and ligand competition reactions.

Materials And Methods: A gadolinium (Gd)-DTPA-BIGA, Gd-DTPA-BMA, Gd-DTPA, or Gd-HP-DO3A solution was mixed with an equimolar solution of zinc (Zn) citrate in 1:1 volume ratio at pH 7.4 in a transmetallation assay.