[Staphylococcus aureus-induced antigen-specific immunosuppression].

In experiments made on noninbred white mice the manifestations of delayed hypersensitivity and the number of antibody-producing cells in regional lymph nodes or the spleen were determined on day 5 after the subcutaneous or intraperitoneal immunization of the animals with sheep red blood cells (SRBC). At the same time the injection of S. aureus antigens simultaneously with SRBC raises the threshold of antigenic sensitivity and decreases the manifestations of cell-mediated and humoral immune response to SRBC.

[Interrelations of cellular and humoral immune response and different doses of sheep erythrocytes in mice].

In experiments on CBA and C57BL/6 mice the generation of antibody-forming cells respectively either in the popliteal lymph nodes or spleen as well as a rate of delayed type hypersensitivity response (DTHR) on the background of subcutaneous (into foot) or intraperitoneal injection of different doses of sheep erythrocytes (from 10(4) to 10(8)) have been studied. In so doing two types of immune response can be isolated on the dependence upon the sensitivity threshold to antigen of DTHR and humoral immunity. Thus in C57BL/6 mice the antigen threshold for DTHR is of one time (in intraperitoneal immunization) or of a two times (in subcutaneous) lower order than for antibody response.