Velocity magnitude estimation with linear arrays using Doppler bandwidth.

The dependence of pulsed wave Doppler bandwidth on parameters typical of linear transducer arrays used in commercial Duplex and color flow mapping systems is investigated experimentally. For a single flow line it is observed that this bandwidth generally depends not only on the scatterer velocity and the beam-to-flow angle, but also on the flow line range and orientation. This is due to the fact that in Duplex and color flow systems the transducer is differently focused in the scan and elevation planes and its aperture and focal lengths are often made to vary, depending on the distance of the flow line from the transducer.

Subharmonic backscattering from ultrasound contrast agents.

The ultrasonic contrast of blood in tissue, which is needed for ultrasonic estimation of tissue perfusion, can be increased by injecting the blood with bubbles or hollow microspheres. It has been shown that an even greater improvement in contrast can be obtained by using the subharmonic generated by irradiated microspheres. By obtaining analytical solutions to the modified RPNNP equation for a coated microbubble, the relationship between the physical parameters of the encapsulated bubble and the threshold pressure is established.

Subharmonic generation from ultrasonic contrast agents.

Ultrasonic contrast agents are used to enhance backscatter from blood and thus aid in delineating blood from surrounding tissue. However, behaviour of contrast agents in an acoustic field is nonlinear and leads to harmonic components in the backscattered signal. Various research groups have investigated second-harmonic emissions.

Onset delay of acoustic second harmonic backscatter from bubbles or microspheres.

A well-known method of enhancing blood detectability in ultrasound imaging of tissues detects the second harmonic of the incident radiation, which is generated by ultrasound contrast agents in the form of bubbles or microspheres that may have been injected into the blood. We report here a delay in the onset of the backscattered second harmonic with respect to the backscattered first harmonic for these agents. This effect, which should limit the axial resolution attainable with harmonic imaging, is investigated by simulation as well as experiment, and its dependence on the incident ultrasonic amplitude and microsphere parameters is established.

Advantages of subharmonic over second harmonic backscatter for contrast-to-tissue echo enhancement.

It is shown experimentally that backscatter from two ultrasonic contrast agents suspended in water or saline contains subharmonics of the incident frequency that are stronger than those backscattered at the same incident pressure from chicken breast. It is also shown that the ratio of subharmonic backscattered from contrast to that backscattered from tissue, is stronger than the ratio of backscattered second harmonic. In consequence, blood that contains contrast should be more easily detectable with respect to tissue if the subharmonic, rather than the second harmonic, is used for imaging.