[Photopolymerizable compositions for bone tissue regeneration].

The review considers methods of manufacturing photopolymerizable compositions for bone tissue repair, as well as polymers and photoinitiators used for this purpose. Their physical and biological properties are described. Examples of light-curing compositions used in biomedicine and tissue engineering are given.

[Mechanical properties of photopolymerisable compositions for the creation of bone and dental tissue equivalents].

The Aim Of The Study: Was to elaborate and assess biocompatible compositions based on oligocarbonate methacrylate filled with hydroxyapatite.

Materials And Methods: The manufacturing methods of the compositions are considered, and their polymerization ability, strength and elastic properties are evaluated.

Results: The highest values of hardness and elasticity were found in the composition containing 0.

Antisolvent 3D Printing of Gene-Activated Scaffolds for Bone Regeneration.

The use of 3D-printed gene-activated bone grafts represents a highly promising approach in the fields of dentistry and orthopedics. Bioresorbable poly-lactic-co-glycolic acid (PLGA) scaffolds, infused with adenoviral constructs that carry osteoinductive factor genes, may provide an effective alternative to existing bone grafts for the reconstruction of extensive bone defects. This study aims to develop and investigate the properties of 3D scaffolds composed of PLGA and adenoviral constructs carrying the BMP2 gene (Ad-BMP2), both in vitro and in vivo.

[Development of Biological Microchips on an Aluminum Support with Cells Made of Brush Polymers].

A method has been developed for manufacturing biological microchips on an aluminum substrate with hydrophilic cells from brush copolymers with the formation of a matrix of cells using photolithography. The surface of aluminum substrates was previously coated with a thin, durable, moderately hydrophobic layer of cross-linked polymer to prevent contact with the aluminum surface of the components used in the analysis of nucleic acids. Aluminum biochip substrates have high thermal conductivity and low heat capacity, which is important for the development of methods for multiplex PCR analysis on a chip.

Protein Biochips with Three-Dimensional Hydrogel or Polymer Brush Elements for the Detection of Human Serum Immunoglobulin E Specific to Inhalation Allergens.

The development of rapid analysis of human serum for the presence of allergen-specific Immunoglobulin E (IgE) is currently important. Consequently, we developed two types of three-dimensional (3D) protein biochips. The first one is a 3D hydrogel biochip containing hydrogel droplets with protein molecules (allergens, immunoglobulins and others).