[Changes in lipids of granulation fibrous tissue in rats at various doses and routes of melatonin administration].

The experimental data indicate that melatonin actively influences time-causes of changes of lipid content in rats tissue during the inflammation process. Its effect depends on a dose, modes of administration (intraperitonial, hypodermic or local) and duration of treatment. A single dose intraperitonial administration of melatonin (4 mg/kg) did not influence lipid content in the granular-fibrose tissue, while repeated injections of this hormone limited the increase in contents of lipids and phospholipids at the 5th and 8th days of regeneration.

Changes in wound field lipids in rat skin.

Intricate dynamics of lipid transformations was detected in rat skin wound field during regeneration. The content of lipids increased in the granulation fibrous tissue during the early period of regeneration and decreased later. On day 23 the regeneration process was over, the formed scar tissue differed from intact skin by the content of many lipid fractions.

Phospholipid composition of granulation and fibrous tissues in rats after local application of melatonin.

We studied the effect of melatonin applied locally in doses of 1.5 and 15 mg/ml on the phospholipid composition of granulation and fibrous tissues in rats at various stages of regeneration. Melatonin (especially in a dose of 1.

[Effect of parenteral administration of melatonin on the biochemical composition of the rat granulation tissue].

The influence of long term parenteral melatonin administration on the biochemical composition of granulation tissue of surgical wounds in rats during healing was investigated. Physiological solution and solutions containing various concentrations of melatonin were subcutaneously injected to the animals within 3 weeks. Control and injected animals were wounded.

[Effect of melatonin on wound healing and various biochemical characteristics of granulation-fibrous tissue in rats].

The influence of melatonin application on wounds healing and biochemical composition of rat regenerating granulation tissue was studied. Melatonin decreased healing rate of wounds. The differences in electrophoretic pattern of proteins extracted by neutral saline solutions were detected.