THE INFLUENCE OF BIFIDOBACTERIUM ANIMALIS AND LECTIN OF B. SUBTILIS IMV B-7724 ON THE ANTITUMOR IMMUNE RESPONSE OF MICE WITH EHRLICH ADENOCARCINOMA.

Aim: To investigate the effect of bacteria of the genus Bifidobacterium and the extracellular metabolite of B. subtilis IMV B-7724 on the antitumor immune response of mice with a model tumor.

Materials And Methods: The study was conducted on Balb/c mice with transplanted solid Ehrlich adenocarcinoma (ACE).

ANALYSIS OF PLASMA MIRNA-497 LEVELS IN THE BLOOD OF PATIENTS WITH BREAST CANCER.

Breast cancer is a heterogeneous disease with a variable clinical course, morphological and clinical features. In clinical observation, we attempted to study the correlation between clinical characteristics of breast cancer patients and plasma miRNA-497 concentration as a possible pathogenic molecular disease factor and a diagnostic indicator. It was established that miRNA-497 levels were significantly higher in the plasma of premenopausal compared to menopausal women, while the opposite is true for healthy women.

Experimental substantiation of the use of hydroxyapatite - tricalcium phosphate bioceramics for replacing bone defects after tumor removal.

Background: Recently, bioactive ceramics based on hydroxyapatite (HAP) and tricalcium phosphate (TCP) have been preferred as implants in bone engineering.

Aim: To study bone regeneration under conditions of filling metaphyseal defects with the original HAP-TCP composition.

Materials And Methods: The experiment was carried out on inbred rats, the observation period was 2, 4, 8 weeks.

Local recurrences after the treatment of soft tissue malignant fibrous histiocytoma (unclassified pleomorphic sarcoma) of the limbs.

Introduction: The treatment of patients with malignant fibrous histiocytoma as well as other soft tissue sarcomas is not sufficiently effective up to date, and has largely changed and reflects the alterations, occurred in oncology as a whole. The number of amputation decreased over the last 10-15 years. Some researchers associate the improvement of treatment outcomes with the development of combined and complex methods.

SUPPORT TOOL FOR DECISION-MAKING IN SELECTING CHEMOTHERAPY TACTICS FOR TREATMENT OF BREAST CANCER PATIENTS.

Breast cancer (BC) is the most commonly occurring oncologic disease in women over the world. The introduction of modern methods of diagnostics and treatment of BC patients allowed achieving some success in the disease control. Chemotherapy (CT) is one of the most effective treatments for BC patients, but the individualization of the choice of effective treatment regimens remains an unresolved issue.