[Effect of homocysteine, cysteine, and their derivatives on the platelet link of hemostasis system].

The influence of homocysteine, homocysteine thiolactone, cysteine and their derivatives on activation and aggregation of human platelets was investigated using the model systems in vitro. It was established that homocysteine and cysteine increased platelet aggregation induced by ADP, epinephrine, or collagen. Their action began in a range of concentrations such as their physiological blood levels (10 microM) and was increasing with the rise of their concentrations.

[Effect of proteins from the Agkistrodon blomhoffii ussuriensis snake venom on platelets in the hemostasis system].

Influence of proteins from the Agkistrodon blomhoffii ussuriensis snake venom on platelet activation and aggregation was developed on different model systems in vitro. It was shown that novel disintegrin (Blomus-B) and phospholipase A2 (Blopholipase) from the venom, activated platelets and inhibited their aggregation. Fibrino(geno)lityc enzyme (Blomulyse) does not activate platelets and has no effect on their aggregation stimulated by collagen, but inhibit ADP and adrenalin-stimulated platelet aggregation.

[Plasminogen activator from Agkistrodon halys halys venom].

Plasminogen activator "Ahh-32" from Agkistrodon halys halys venom has been isolated and purified using affinity and ion-exchange chromatography. The purified enzyme consists of the single peptide-chain with molecular weigth of 32 kDa. It can convert free plasminogen into active form--plasmin.

[Characterization of platelets aggregation inhibitor from Agkistrodon blomhoffii ussuriensis snake venom].

Platelet aggregation inhibitor--"Blomus-B" from Agkistrodon blomhoffii ussuriensis venom has been isolated by affinity and ion-exchange chromatography. The purified inhibitor is a novel non-enzymatic single-chain protein with molecular weigth of 13 kDa. "Blomus-B" causes a change of platelets shape and takes effect on ADP- and adrenalin-induced platelet aggregation.

[Magnetic resonance of magnetically ordered nanoscale particles in brain tissue].

Nature of unusual resonance signals, which can be registered by spectrometers of electron paramagnetic resonance, are studied in different weakly mineralized biological tissues. The experiments are carried out in a three-centimeter range of waves on human and animal (rats) brain tissues and on the organic component of mollusk shells. In these materials the unusual resonance signals, which have unique dynamic characteristics, are registered.