[Subtotal whole-body irradiation as the 1st phase in the therapy of patients with stage-IIIB and -IV lymphogranulomatosis: the immediate effects].

Systemic radiotherapy in the form of subtotal radiation of the body (STRB) was provided for the first time to 23 patients with lymphogranulomatosis, stages IIIB-IVB, as the first stage of anticancer treatment as an alternative to chemotherapy. STRB was established to produce marked immediate and steady anticancer effects manifesting in the removal of intoxication, a reduction of the size of the lymph nodes and specific infiltration in the lungs, and the lowering of the ESR. The duration of STRB was 10.

[Optimization of the intracavitary irradiation of patients with cancer of the endometrium].

Twelve variants of uterine cavity structure were defined on analysis of 52 hysterocervicograms performed in patients with cancer of the uterine body. Using the method of linear programming, the most effective schemes for the location of radiation sources were proposed to ensure optimum dose distribution in intracavitary irradiation. Sources I and II were the main contributors to dose distribution.

[Basis for the use of enclosed 125I sources for interstitial radiation therapy].

Experimental models of closed sources of 125I low energy photon radiation in the titanium capsules sealed by means of pulsed laser welding were designed. Doses in the tissue equivalent medium from a single 125I point source were calculated using ES-1022 computer, tables for calculating dose fields in different layouts of sources were drawn, and layout parameters in preset doses calculated. Using the 125I source in interstitial irradiation of murine breast tumors one managed to establish the local nature of tissues corresponding to the calculated dose distribution for photon radiation with the energy of 27-35 keV.