Publications by authors named "V L Jacobs"
Merkel cell carcinoma (MCC) is an aggressive cutaneous malignancy with a poor prognosis. One of the major mechanisms of immune evasion in MCC involves downregulation of major histocompatibility complex class I (MHC-I). Anti-PD-1/programmed death ligand 1 checkpoint inhibitors have revolutionized treatment for MCC, producing objective responses in approximately 50% of patients, and are now the standard of care; however, a substantial proportion of patients either fail to respond or develop resistance to checkpoint inhibitors.
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- Pancreatic adenocarcinoma (PDAC) is a challenging cancer to treat with immunotherapies, but certain intratumoral structures called tertiary lymphoid structures (TLS) have been linked to better patient survival outcomes.
- A comprehensive study analyzed 26 PDAC tumors using advanced techniques like machine learning and spatial transcriptomics to better understand the role of TLS within tumors.
- The findings revealed specific gene expression patterns in TLS that correlate with improved survival, highlighting the importance of TLS maturation and its interactions with immune cells and the tumor environment.
In conversation, recognizing social actions (similar to 'speech acts') early is important to quickly understand the speaker's intended message and to provide a fast response. Fast turns are typical for fundamental social actions like questions, since a long gap can indicate a dispreferred response. In multimodal face-to-face interaction, visual signals may contribute to this fast dynamic.
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- - Atrial fibrillation (AF) increases the risk of cognitive decline and dementia, especially in patients with a history of stroke; anticoagulation strategies can influence long-term dementia risk in AF patients.
- - The CAF Trial examined the effects of dabigatran and warfarin on cognitive health in patients with non-valvular AF and found no significant changes in cognitive function or dementia occurrence over 24 months.
- - Both dabigatran and well-managed warfarin therapy showed similar outcomes regarding stroke, cognitive decline, and dementia within two years, leading to the conclusion that either anticoagulation strategy is viable without the need for a larger study.
Article Synopsis
- - A quality improvement (QI) intervention was conducted to assess its effect on the time taken to administer biologic or small molecule medications to patients with inflammatory bowel disease (IBD), focusing on reducing delays which can lead to negative health outcomes.
- - Data was collected from 400 patients across two cohorts (baseline and postintervention), and results showed a significant decrease in the median time to medication administration (from 30 to 26 days) and a drop in emergency room visits.
- - The study recommends the use of time to administration of biologics (TABS) as a key quality metric for evaluating treatment efficiency in IBD and suggests further research on QI interventions and patient education regarding prescription insurance.