Publications by authors named "V L Isakov"
Background: The global burden of metabolic diseases is increasing, but estimates of their impact on primary liver cancer are uncertain. We aimed to assess the global burden of primary liver cancer attributable to metabolic risk factors, including high body mass index (BMI) and high fasting plasma glucose (FPG) levels, between 1990 and 2021.
Methods: The total number and age-standardized rates of deaths and disability-adjusted life years (DALYs) from primary liver cancer attributable to each metabolic risk factor were extracted from the Global Burden of Disease Study 1990-2021.
Epidemiologic studies of ambient fine particulate matter (PM) and ozone (O) often use outdoor concentrations from central-site monitors or air quality model estimates as exposure surrogates, which can result in exposure errors. We previously developed an exposure model called TracMyAir, which is an iPhone application that determines seven tiers of individual-level exposure metrics for ambient PM and O using outdoor concentrations, home building characteristics, weather, time-activities. The exposure metrics with increasing information needs and complexity include: outdoor concentration (C, Tier 1), building infiltration factor (F, Tier 2), indoor concentration (C, Tier 3), time spent in microenvironments (ME) (T, Tier 4), personal exposure factor (F, Tier 5), exposure (E, Tier 6), and inhaled dose (D, Tier 7).
View Article and Find Full Text PDFModel spherical polystyrene particles are studied to understand the interactions of microplastics with organic pollutants. Analysis of the experimental results presented in the literature is complicated since researchers use different types and concentrations of particles, durations of tests, etc. In addition, there is little information on the effect of the structure of the surface layer of polystyrene particles on the processes under study, and the question of the effect of the shape of polystyrene particles remains open.
View Article and Find Full Text PDFArticle Synopsis
- - Patients with non-alcoholic fatty liver disease (NAFLD) show impaired nutritional habits, and certain dietary patterns like the Mediterranean, vegetarian, and DASH diets can help prevent the disease.
- - The study involved analyzing the diets of 613 Russian patients with NAFLD and a control group, using data collected from 2021 to 2023, including assessment of liver conditions through advanced imaging techniques.
- - Findings revealed significant differences in food intake between NAFLD patients and healthy individuals, with NAFLD patients consuming less dairy, legumes, healthy fats, fish, vegetables, and nuts, while consuming more meat, compared to recommended dietary patterns.
Article Synopsis
- The study aimed to investigate how type 2 diabetes mellitus (DM2) affects liver steatosis (fatty liver) and fibrosis in patients with non-alcoholic fatty liver disease (NAFLD).
- A total of 2989 patients were examined, sorted into groups based on the presence of DM2 and NAFLD, with various health metrics analyzed to measure liver health and body composition.
- Results indicated that patients with both NAFLD and DM2 had higher body weight, worse liver health—showing more severe steatosis and fibrosis—along with poorer lipid metabolism compared to those with NAFLD without DM2.