Publications by authors named "V L Goriachkina"

This literature review summarizes the data on the general principles of the structure and functions of keratinocytes, melanocytes, dendritic cells (DC) and tactile epithelial cells. Special attention is paid to the process of keratinization, the formation of lipid barrier of the stratum corneum. The problem of the stem and transitional cell surface markers is discussed.

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Literature and original authors' data on topography, structural organization and function of secretory bronchiolar Clara cells of the lungs in various representatives of mammals and humans are analyzed. Involvement of Clara cells in bronchiolar clearance, metabolization of xenobiotics and carcinogenic substances, synthesis of specific low molecular proteins (SLP), antimediators of inflammation. Special attention is drawn to the SLP properties; proteins with antiprotease properties are revealed among SLP.

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Our work was aimed to study glycogen-like granules in muscular fibres mitochondria under action of different factors (maximum physical load, hypokinesia and saturation of the organism with carbohydrates). Swelled mitochondria with glycogen-like granules were shown in muscular fibres in physical load. Similar mitochondria but without granules were observed in hypokinesia.

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Using dispersive and factor analyses of the serial sections of the skeletal muscle tissue it has been shown that the activity of myosin Ca-ATPase is the most essential parameter in the definition of the phenotype of skeletal muscle fiber according to its functional and metabolic characteristics. The stability of this parameter during different functional loadings permits to recommend it as the major one in the definition of the fiber phenotype.

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NADH-tetrazolium reductase and succinate dehydrogenase activity, glycogen concentration and ultrastructure of muscular fiber of a human being was studied before and after single physical load to refusal. The revealed individual peculiarities of fiber reaction in different people allow to divide all tested people into two subgroups according to the change of succinate dehydrogenase activity.

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