[Antithrombotic effect of catalase and chondroitin sulfate derivatives in arterial damage in rats].

The antithrombotic action of catalase and chondroitin sulfate derivatives was studied on the rat arterial thrombosis induced by treatment of vessel with ferrous chloride solution. The effect of native or chondroitin sulfate modified catalase, as well as the mixture of native catalase and free chondroitin sulfate in ratio which is equal to their content in conjugate was compared in respect to corresponding doses according to active catalase content. The antithrombotic action of conjugate and its component mixture is rather similar with each other and significantly exceeds the effect of native enzyme.