[Computer simulation of hydraulic flows in a human eye].

A two-dimensional computer model was developed to describe hydraulic flows inside the human eye. The flow field was described by coupled Navier-Stokes and Darcy equations. The velocity and pressure profiles in the chambers, the wall, and the vitreous body of the normal eye were obtained using the finite-element method.

[On a classification of changes in the eye fundus as observed in diabetes mellitus].

A classification of diabetic retinopathy and diabetic maculopathy as well as treatment schemes for each stage, which were worked out by the authors, are described in the paper. A stage free of any diabetic changes in the eye fundus is isolated, within the suggested classification, as well as the notion of a high-risk diabetic retinopathy is defined with more precision and in accordance with the modern understanding of importance of the vitreous-retinal interaction and of compensation of carbohydrate metabolism in the disease pathogenesis. Finally, an original classification of diabetic macular edema was introduced.

[Changes in general hemostasis in patients with diabetic retinopathy].

The hemostasis system was analyzed in 106 patients with diabetes mellitus, including 86 patients with diabetic retinopathy. Parameters of coagulogram and thromboelastogram as well as platelets aggregation, stimulated by collagen, were examined in all patients. Besides, the fibrinolytic activity of blood plasma as well as the concentration of plasminogen, fibrinogen and of fibrin-degradation products were evaluated.

[Pharmacokinetics of recombinant pro-urokinase ocular dosage form].

Thrombolytic enzymes are widely used in the treatment of vascular diseases of the eyes and of intraocular hemorrhages. We studied the pharmacokinetics of recombinant prourokinase (proRUK) in ocular structures after its intravitreal administration and subtenon's implantation of collagen infusion system (SICIS). Kinetic parameters of accumulation of labeled proRUK in ocular structures were obtained.