Effect of Contact Lens Solutions in Stabilizing the Activity of Tear Lysozyme.

Purpose: Interactions between tear proteins and the interfaces of contact lenses can be complex and can influence contact lens wear success. Tear proteins, including lysozyme, function to maintain the balance of ocular surface homeostasis, as evidenced by the effects of its conformation relative to stabilizing the tear film and its potential impact on corneal epithelial cells. Contact lens manufacturers include components in lens care and blister package solutions to help stabilize the tear film and preserve homeostasis.

Correction for Fletcher et al., "Vaccine Potential of the Neisseria meningitidis 2086 Lipoprotein".

[This corrects the article DOI: 10.1128/IAI.72.

Retention of conditioning agent hyaluronan on hydrogel contact lenses.

Hyaluronan, a member of the glycosaminoglycan family of biological polysaccharides, is a high-molecular-weight disaccharide polymer found throughout the human body, particularly in the eye. Bausch+Lomb Biotrue™ multi-purpose solution contains hyaluronan as a lens conditioning agent. The retention of hyaluronan from Biotrue multi-purpose solution to a variety of hydrogel contact lenses was evaluated over time.

Comparative evaluation of multi-purpose solutions in the stabilization of tear lysozyme.

The range and extent of tear proteins removed by various multi-purpose solutions has been investigated, but there is little information in the literature about their ability to prevent denaturation of tear proteins, particularly lysozyme. The purpose of this study was to determine the ability of Bausch+Lomb Biotrue™ multi-purpose solution and other care solutions to affect denaturation of lysozyme using a lysozyme activity assay. The test solutions used were: Biotrue multi-purpose solution, Bausch+Lomb renu(®) fresh™, formerly ReNu MultiPlus(®), Alcon OPTI-FREE RepleniSH, Alcon OPTI-FREE EXPRESS, CIBA VISION AQuify, and AMO COMPLETE Multi-Purpose Solution Easy Rub Formula.