Publications by authors named "V L Bakir"
With growing commercial, regulatory and scholarly interest in use of Artificial Intelligence (AI) to profile and interact with human emotion ("emotional AI"), attention is turning to its capacity for people, relating to factors impacting on a person's decisions and behavior. Given prior social disquiet about AI and profiling technologies, surprisingly little is known on people's views on the benefits and harms of emotional AI technologies, especially their capacity for manipulation. This matters because regulators of AI (such as in the European Union and the UK) wish to stimulate AI innovation, minimize harms and build public trust in these systems, but to do so they should understand the public's expectations.
View Article and Find Full Text PDFPolycystic ovary syndrome (PCOS) is one of the most common endocrine diseases in women. In recent years, the effects of vitamin D receptor (VDR) gene variants and VitD3 levels on clinical features of PCOS have been frequently described. In this study, we aimed to determine the relationship between VDR , and gene variants and VitD3 levels in PCOS patients.
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- Cefiderocol is effective against carbapenem-resistant bacteria, but its susceptibility varies based on different interpretive criteria from EUCAST and CLSI.
- Researchers tested 254 CRK blood isolates and found significant differences in resistance rates to cefiderocol when applying EUCAST versus CLSI criteria.
- High cefiderocol resistance rates were especially noted among NDM producers using EUCAST guidelines, leading to the recommendation that these criteria should be prioritized for testing until more clinical data is available.
Article Synopsis
- Aminoglycosides are important for treating infections caused by carbapenemase-producing bacteria (CPK), but resistance to these antibiotics is rising, primarily due to 16S rRNA methyltransferases (RMTs) often found alongside NDM genes.
- In a study of 181 invasive CPK isolates, 60% were resistant to amikacin, gentamicin, and tobramycin, with most of the resistant isolates carrying RMTs, particularly ArmA and RmtC.
- The study found that the resistance is largely linked to specific clonal types, particularly ST2096 and ST14, which are associated with certain carbapenemases and other resistance genes, suggesting that clonal spread is a
Ceftazidime-avibactam exhibits good in vitro activity against carbapenem resistant Klebsiella carrying OXA-48-like enzymes. We tested two hundred unique carbapenem resistant Klebsiella blood stream isolates (71% with single OXA-48-like carbapenemases, including OXA-48, n = 62; OXA-232, n = 57; OXA-244, n = 17; OXA-181, n = 5) that were collected as part of a multicentre study against ceftazidime-avibactam using Etest (bioMérieux, Marcyl'Étoile, France), 10/4 μg disc (Thermo Fisher) and Sensititre Gram Negative EURGNCOL Plates (Lyophilized panels, Sensititre, Thermo Fisher) with the aim of comparing the performances of the Etest and disc to that of Sensititre. Ceftazidime-avibactam MIC was 2/>16 mg/L for the entire collection and was 2/4 mg/L for single OXA-48-like producers.
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