Science and technical priorities for private sector action to address biodiversity loss.

Target 15 of the Kunming-Montreal Global Biodiversity Framework recognizes the importance of the private sector monitoring, assessing and disclosing biodiversity-related risks, dependencies and impacts. Many businesses and financial institutions are progressing with science-based assessments, targets and disclosures and integrating into strategy, risk management and capital allocation decisions. Developments will continue in response to investor expectations, emerging corporate sustainability reporting regulations in Europe, China and elsewhere and evolving global sustainability reporting standards.

Untargeted metabolomics and lipidomics in COVID-19 patient plasma reveals disease severity biomarkers.

Introduction: Coronavirus disease 2019 (COVID-19) has widely varying clinical severity. Currently, no single marker or panel of markers is considered standard of care for prediction of COVID-19 disease progression. The goal of this study is to gain mechanistic insights at the molecular level and to discover predictive biomarkers of severity of infection and outcomes among COVID-19 patients.

Management of Isolated Medial Orbital Wall Fracture with Intraoral Periapical X-ray Film: A Case Report with Literature Review.

Fractures of the walls of the orbit can cause a number of problems which include diplopia, extraocular muscle entrapment, enophthalmos, etc. Medial wall fractures are the most common among all orbital wall fractures, and their anatomical reconstruction is relatively challenging. Various autogenous and synthetic materials have been tried over the years, and each has its own advantages and limitations.

Identifying effective evolutionary strategies-based protocol for uncovering reaction kinetic parameters under the effect of measurement noises.

Background: The transition from explanative modeling of fitted data to the predictive modeling of unseen data for systems biology endeavors necessitates the effective recovery of reaction parameters. Yet, the relative efficacy of optimization algorithms in doing so remains under-studied, as to the specific reaction kinetics and the effect of measurement noises. To this end, we simulate the reactions of an artificial pathway using 4 kinetic formulations: generalized mass action (GMA), Michaelis-Menten, linear-logarithmic, and convenience kinetics.

Inhibition of hepatic stellate cell activation by nutraceuticals: an emphasis on mechanisms of action.

Liver diseases emerge as a serious threat to humans worldwide due to increasing morbidity and mortality. Liver disease related deaths accounts for one third of all disease related death globally. A simple fatty liver if unattended advances further to liver fibrosis, cirrhosis and hepatocellular carcinoma.