Publications by authors named "V Kulda"
Article Synopsis
- Breast cancer is one of the most commonly diagnosed cancers globally, and while survival rates have improved due to advancements in diagnostics and treatments, many survivors face significant long-term health issues that negatively impact their quality of life.* -
- Common problems reported by survivors include chronic fatigue, pain, sleep disorders, and mental health issues, all of which may stem from mitochondrial dysfunction and disrupted bodily balance.* -
- The article proposes a novel holistic approach focusing on improving mitochondrial health through tailored assessments and lifestyle changes, aimed at enhancing the overall well-being and rehabilitation of breast cancer survivors.*
Background/aim: The management of patients with clear cell renal cell carcinoma (ccRCC) includes prognosis assessment based on TNM classification and biochemical markers. This approach stratifies patients with advanced ccRCC into groups of favorable, intermediate, and poor prognosis. The aim of the study was to improve prognosis estimation using microRNAs involved in the pathogenesis of ccRCC.
View Article and Find Full Text PDFBackground/aim: Targeted therapy has become increasingly important in treating lung adenocarcinoma, the most common subtype of lung cancer. Next-generation sequencing (NGS) enables precise identification of specific genetic alterations in individual tumor tissues, thereby guiding targeted therapy selection. This study aimed to analyze mutations present in adenocarcinoma tissues using NGS, assess the benefit of targeted therapy and evaluate the progress in availability of targeted therapies over last five years.
View Article and Find Full Text PDFBone regeneration after injury or after surgical bone removal due to disease is a serious medical challenge. A variety of materials are being tested to replace a missing bone or tooth. Regeneration requires cells capable of proliferation and differentiation in bone tissue.
View Article and Find Full Text PDFThe concept of liquid biopsy as an analysis tool for non-solid tissue carried out for the purpose of providing information about solid tumors was introduced approximately 20 years ago. Additional to the detection of circulating tumor cells (CTCs), the liquid biopsy approach quickly included the analysis of circulating tumor DNA (ctDNA) and other tumor-derived markers such as circulating cell-free RNA or extracellular vesicles. Liquid biopsy is a non-invasive technique for detecting multiple cancer-associated biomarkers that is easy to obtain and can reflect the characteristics of the entire tumor mass.
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