Publications by authors named "V Kremen"
Article Synopsis
- The study aimed to create a mobile platform called ARTiE Watch to objectively and consistently assess behavioral responsiveness in people with epilepsy during and after seizures, improving current subjective methods.
- Patients were recruited to wear the ARTiE Watch, which paired with a smartphone app to remotely initiate standardized tests evaluating motor, language, and memory responses upon seizure identification.
- Results showed that participants had significantly decreased behavioral responsiveness during seizures compared to their baseline, with marked differences noted in specific types of seizures like bilateral tonic-clonic seizures.
Article Synopsis
- Obstructive sleep apnoea (OSA) is linked to a higher risk of cognitive impairment and dementia, potentially involving Alzheimer's disease pathology.
- This study focused on the relationship between sleep patterns (specifically non-rapid eye movement slow-wave activity or SWA) and the accumulation of amyloid, a protein associated with Alzheimer's, in older adults with OSA.
- The results showed that increased slow oscillation (SO) activity in sleep was correlated with greater amyloid accumulation, while certain sleep patterns also indicated a potential reduction in amyloid buildup.
Article Synopsis
- TREM2 is a receptor found in microglia, crucial for their functions like proliferation and phagocytosis, and plays a key role in neurodegenerative diseases.
- Research using TREM2 knockout mice in a seizure model showed that lacking TREM2 worsened seizure pathology and increased the frequency of recurrent seizures.
- In humans, lower levels of a microglial phagocytic marker, CD68, were associated with more severe seizure histories, suggesting that TREM2 and microglial phagocytosis are vital in epilepsy development.
The network nature of focal epilepsy is exemplified by mesial temporal lobe epilepsy (mTLE), characterized by focal seizures originating from the mesial temporal neocortex, amygdala, and hippocampus. The mTLE network hypothesis is evident in seizure semiology and interictal comorbidities, both reflecting limbic network dysfunction. The network generating seizures also supports essential physiological functions, including memory, emotion, mood, and sleep.
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