Publications by authors named "V Kondylis"
RIPK1 is a multi-functional kinase that regulates cell death and inflammation and has been implicated in the pathogenesis of inflammatory diseases. RIPK1 acts in a kinase-dependent and kinase-independent manner to promote or suppress apoptosis and necroptosis, but the underlying mechanisms remain poorly understood. Here, we show that a mutation (R588E) disrupting the RIPK1 death domain (DD) caused perinatal lethality induced by ZBP1-mediated necroptosis.
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- Digested fats are absorbed by intestinal cells (enterocytes) and converted into pre-chylomicrons before being sent to the bloodstream, but the role of mitochondria in this process is not well understood.
- *Research shows that when mitochondrial functions are impaired in enterocytes, it disrupts the production of chylomicrons and the transport of fats to other body parts, leading to fat accumulation in the small intestine.
- *Specifically, a lack of mitochondrial protein DARS2 results in large lipid droplets in enterocytes and problems with the Golgi apparatus, highlighting the critical role of mitochondria in processing dietary fats in the intestines, which could have implications for diseases affecting energy metabolism.
Tissues within an organism and even cell types within a tissue can age with different velocities. However, it is unclear whether cells of one type experience different aging trajectories within a tissue depending on their spatial location. Here, we used spatial transcriptomics in combination with single-cell ATAC-seq and RNA-seq, lipidomics and functional assays to address how cells in the male murine liver are affected by age-related changes in the microenvironment.
View Article and Find Full Text PDFMicroRNA dysregulation is a hallmark of hepatocellular carcinoma (HCC), leading to tumor growth and metastasis. Previous screening on patient specimens identified miR-198 as the most downregulated miRNA in HCC. Here, we show that miR-198 compensation leads to self-release into extracellular vesicles (EVs).
View Article and Find Full Text PDFOver the last decades, organoids have been established from most of the tissue-resident stem and iPS cells. They hold great promise for our understanding of mammalian organ development, but also for the study of disease or even personalised medicine. In recent years, several reports hinted at intraculture organoid variability, but a systematic analysis of such heterogeneity has not been performed before.
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