Rare host variants in ciliary expressed genes contribute to COVID-19 severity in Bulgarian patients.

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a pneumonia with extremely heterogeneous clinical presentation, ranging from asymptomatic to severely ill patients. Previous studies have reported links between the presence of host genetic variants and the outcome of the COVID-19 infection. In our study, we used whole exome sequencing in a cohort of 444 SARS-CoV-2 patients, admitted to hospital in the period October-2020-April-2022, to search for associations between rare pathogenic/potentially pathogenic variants and COVID-19 progression.

Carbon-Based Composites with Mixed Phosphate-Pyrophosphates with Improved Electrochemical Performance at Elevated Temperature.

Sodium iron phosphate-pyrophosphate, NaFe(PO)PO (NFPP) emerges as an excellent cathode material for sodium-ion batteries. Because of lower electronic conductivity, its electrochemical performance depends drastically on the synthesis method. Herein, we provide a simple and unified method for synthesis of composites between NFPP and reduced graphene oxide (rGO) and standard carbon black, designed as electrode materials for both sodium- and lithium-ion batteries.

A sustained decrease in serum CD83 in pregnant women.

Maternal immunity regulates tolerance to the semi-allogeneic fetus during pregnancy via modulation of immune regulatory factors. The serum factor CD83 is known to undergo changes during gestation in mice. Here we characterize serum levels of CD83 in women for the first time, revealing a consistent decline as pregnancy progresses and recovery to non-pregnant levels in miscarriage.

Dual-Ion Intercalation Chemistry Enabling Hybrid Metal-Ion Batteries.

To outline the role of dual-ion intercalation chemistry to reach sustainable energy storage, the present Review aimed to compare two types of batteries: widely accepted dual-ion batteries based on cationic and anionic co-intercalation versus newly emerged hybrid metal-ion batteries using the co-intercalation of cations only. Among different charge carrier cations, the focus was on the materials able to co-intercalate monovalent ions (such Li and Na , Li and K , Na and K , etc.) or couples of mono- and multivalent ions (Li and Mg , Na and Mg , Na and Zn , H and Zn , etc.

Evaluation of Soluble CD90: Potential for Diagnostic Significance in Endometriosis Patients.

Background: Endometriosis is a chronic and debilitating gynecologic disorder, driven by endocrine and immune dysfunctions, which lead to poor endometrial differentiation and attenuated fertility. Escape from immune surveillance and involvement of inflammatory mechanisms appear to be factors in disease progression. Current diagnostic guidelines for endometriosis still lack an efficient biomarker.