Publications by authors named "V Klochko"
The purposes of the research were to study the prevalence of C-344T polymorphism and the distribution of aldosterone synthase gene (CYP11B2) genotypes, to analyze the association of aldosterone concentration with aldosterone synthase gene genotypes, to study the features of left ventricular hypertrophy (LVH) by echocardioscopy and identify their association with different genotypes of the aldosterone synthase gene in young patients with arterial hypertension (AH), depending on the presence or absence of concomitant obesity (or overweight). 123 young patients with essential AH (18-44 years old) were examined, the average age was (32,83±0,58) years old, the male/female ratio was 72/51 respectively. All patients were divided into 3 groups: group 1 (n=41) with normal body weight; group 2 (n=40) with overweight; group 3 (n=42) -with obesity.
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- The work studies how the diagnosis, treatment, and prevention of acute rheumatic fever (ARF) and chronic rheumatic heart disease (RHD) have changed over time, using both literature and personal observations.
- Updated diagnostic criteria and advancements in echocardiography can help identify patients earlier, potentially leading to better treatment outcomes.
- The research highlights the relationship between ARF/RHD prevalence and a country's economic status, while also noting that factors like antibiotic resistance and increased travel may contribute to new outbreaks, suggesting that a layered prevention strategy is essential.
The aim of the study was to determine the presence of various organ-specific and organ - nonspecific autoantibodies and their association with Sjogren's syndrome - one of the most pervasive autoimmune disorders that affects entire body. The etiology of Sjogren's syndrome is not clearly understood. It may be due combination of factors: inherited, hormonal, infection from virus.
View Article and Find Full Text PDFTo determine the computer-predicted anticancer activity of mupirocin and to compare its activities with those determined for another polyene antibiotic, batumin. Molecular docking, cytotoxicity assays, cell microscopy and cell cycle progression were studied in cancer and nontumorigenic cell lines. Cytotoxicity of mupirocin against several cancerous cell lines was detected with the highest one (IC = 5.
View Article and Find Full Text PDFAim: To determine the computer-predicted anticancer activity of antibiotic batumin.
Materials & Methods: Cytotoxicity assays, cell morphology microscopy and cell cycle progression were studied in cancer and nontumorigenic cell lines. An in vivo experiment on Lewis lung carcinoma (3LL)-transplanted mice was conducted to evaluate potential antimetastatic.